TY - JOUR AU - Willmott, Heather AU - Gochanour, Caroline AU - Ding, Kai AU - Reese, Jessica AU - Lee, Elisa AU - Zhang, Ying PY - 2025 TI - Two Modeling Strategies in Analyzing Clustered Time-to-Event Data: the Strong Heart Family Study T2 - Preventing Chronic Disease JO - Prev Chronic Dis SP - E12 VL - 22 CY - Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. N2 - Researchers need applicable tools to analyze and account for familial relatedness when working with family study data. In this brief article, we describe the application of 2 modeling strategies for studying the association between leukocyte telomere length and incident stroke based on data collected in the Strong Heart Family Study: the shared frailty model and the marginal Cox proportional hazards model. Although these modeling strategies are based on different theoretical frameworks, their results were similar. Future simulation study may help us to better understand the limitations and performance of each strategy in a controlled environment. SN - 1545-1151 UR - https://doi.org/10.5888/pcd22.240387 DO - 10.5888/pcd22.240387 ER -