Incidence and Risk Factors for Symptomatic Human Metapneumovirus (hMPV) Infection in a Community Cohort (CASCADIA), Oregon and Washington, June 2022¨CMarch 2024

What to know

  • Presentation Day/Time: Thursday, April 24, 9:00–10:25 am
  • Presenter: Mila Shakya, DPhil, MPH, MBSS, EIS officer assigned to the National Center for Immunization and Respiratory Diseases, Coronavirus and Other Respiratory Viruses Division
Mila Shakya, DPhil, MPH, MBSS

What did we do?

  • We assessed incidence and risk factors for symptomatic human metapneumovirus (hMPV) infection in a community-based cohort study in Oregon and Washington.

What did we find?

  • Overall, 307/3,557 participants (8.6%) had symptomatic hMPV.
  • Those with hMPV most frequently reported cough (80.1%), nasal congestion (71.7%) and sore throat (38.1%).
  • Among 254 (82.7%) hMPV-positive participants with complete information, 69 (27.2%) missed work/school, 19 (7.5%) had medically-attended illness, and 2 (0.8%) were hospitalized.
  • Average incidence of symptomatic hMPV infection was 7.5 per 100 persons per year.
  • Incidence was highest during March-May and among children aged 2–5 years, and clustered in households.

Why does it matter?

  • Approximately 7% of persons aged <50 years may experience symptomatic hMPV infection annually.
  • Although most illnesses are mild, a substantial proportion result in absenteeism, highlighting the impact that even mild infection can have on daily activities, including work, school, and child care facility attendance.
  • Understanding hMPV epidemiology can guide surveillance definitions, clinical testing, and prioritization of prevention strategies.

***This presentation has updated data that will be shared at the EIS Conference.

Abstract Category: Human Metapneumovirus (hMPV)